The Major Immediate-Early Protein IE2 of Human <i>Cytomegalovirus</i> Is Sufficient to Induce Proteasomal Degradation of CD83 on Mature Dendritic Cells.

IE2 positive cells showed a highly significant ( p < 0.0001) down-regulation of CD83 surface expression ( Figure 5A , white bar) which could be prevented by the addition of the proteasome inhibitor MG-132 ( Figure 5A , gray bar).

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