Polo-like kinase 3 and phosphoT273 caspase-8 are associated with improved local tumor control and survival in patients with anal carcinoma treated with concomitant chemoradiotherapy.

In that context, we here demonstrate a highly significant correlation between Plk3 and pT273 caspase-8 detection (Table 2 ) and thus phosphorylation of caspase 8 may represent a mechanism by which different levels of Plk3 expression in tumor cells may stimulate the extrinsic apoptotic machinery.

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