Weight and Body Composition Compartments do Not Predict Therapeutic Thiopurine Metabolite Levels in Inflammatory Bowel Disease.

32 Area under the curve of plasma mercaptopurine concentration over time has been shown to correlate with clinical response and toxicity in a similar clinical setting, 33 but no correlation exists between oral 6MP dose (in mg/m 2 of body surface area) and area under the curve, 34 implying weight and height may not be significant factors in determining therapeutic dosing.

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