Exploring the genetic architecture of inflammatory bowel disease by whole-genome sequencing identifies association at ADCY7.

While we estimate that this stringent quality control produced well calibrated association test statistics for more than 99% of sites, this analysis yielded many extremely significant p-values at SNPs outside of known loci (e.g. ~7,000 with p < 10 -15 ), 95% of which had an allele frequency below 5%.

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