marginally significantP =0.014
marginally non-significantP =0.067
X-linked d N / d S is greater though marginally non-significant for X-linked genes (86 genes, permutation test with 1,000 replicates, P =0.067) relative to the autosomes (4,755 genes), due to a marginally significant increase in d N (permutation test with 1000 replicates, P =0.014) ( Supplementary Table 6 , Supplementary Fig. 5 ).