The Radiation Therapy Oncology Group initiated phase II trial 9514 and showed a significant reduction in distant metastases, with a highly significant gain in DFS and OS after an aggressive neoadjuvant chemotherapy. 14 , 15 This regimen also led to long-term survival benefits. 16 Recently the NCCN soft tissue tumor and treatment guidelines (Online: http://www.nccn.org/professionals/physician_gls/pdf/sarcoma.pdf) have emphasized the importance of adjuvant and neoadjuvant chemotherapy before surgery.
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Combination of Cisplatin, Ifosfamide, and Adriamycin as Neoadjuvant Chemotherapy for Extremity Soft Tissue Sarcoma: A Report of Twenty-Eight Patients.
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