highly significantP < .001
borderline significantP = .13
This difference was significant for A-07 and U-25 tumors ( P = .035 and P = .026, respectively; Figure 3 C ), borderline significant for D-12 and R-18 tumors ( P = .13 and P = .14, respectively; Figure 3 C ), and highly significant when A-07, U-25, D-12, and R-18 tumors were pooled together ( P < .001; Figure 3 D ).