Global DNA methylation levels are altered by modifiable clinical manipulations in assisted reproductive technologies.

For both maternal and paternal age, global methylation differences between ART and controls, as measured by both LUMA and LINE1 , were highly significant in the younger parental age group (≤35 years), suggesting that the difference in methylation between ART and control groups (Additional file 1 ) is not a result of the older average age of ART patients.

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