Variability in delivered dose and respirable delivered dose from nebulizers: are current regulatory testing guidelines sufficient to produce meaningful information?

19 – 22 Although other factors may affect real-life device use, eg, peak inspiratory flow and tidal volume, to enable an identification of the effects of the highly significant I:E ratio without the complication of having to resolve effects from the other variables, I:E ratio was as far as possible isolated as a single variable.

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