α-Tocopherol at Nanomolar Concentration Protects Cortical Neurons against Oxidative Stress.

The data obtained provide evidence that the average inhibition of H 2 O 2 -initiated ROS accumulation by preincubation with 100 μM and 100 nM α-T for 18 h was 75.9% ± 3.1% and 54.8% ± 7.1%, respectively; the antioxidative effect of micromolar and nanomolar α-T was highly significant ( p < 0.001 and p < 0.01, respectively), the effect of 100 μM α-T being more pronounced than the effect of 100 nM α-T under the experimental conditions used ( p < 0.05, n = 4).

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