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Tropomyosin-1 acts as a potential tumor suppressor in human oral squamous cell carcinoma.

PLoS One · 2017 · PMC5300227 · PMID 28182650

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an increasing trendno p-value reported
The expression of tumor-suppressor genes could rapidly decrease in a transient manner during the precancerous stage and finally recover in the advanced stage, which could present as an increasing trend in expression in comparison to the precancerous stage.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.