Alcoholic, Nonalcoholic, and Toxicant-Associated Steatohepatitis: Mechanistic Similarities and Differences.

70 Studies in humans and animals suggest that NKT cells may be significant contributors to inflammation, cell death, and fibrosis in NAFLD. 69 , 71 , 72 Moreover, evidence demonstrates a significant decrease of CD4 + regulatory T cells in a high fat diet mouse model of fatty liver. 73 , 74 Recently, another subset of helper T cells, T H 17 cells, that secrete IL-17 and induce inflammation via neutrophils has been identified and is thought to play a role in fatty liver.

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