A two-stage inter-rater approach for enrichment testing of variants associated with multiple traits.

In the MAGIC data under analysis, this SNP is genome-wide significant for FG ( P -value 2.67 × 10 −8 ; ABF 5.63) and highly significant for FI ( P -value 3.36 × 10 −7 ; ABF 4.10); rs6984305 is also in LD ( r 2 =0.614) with a known genome-wide significant FG (interaction with BMI)-associated SNP, rs4841132. 5 Several SNPs are of interest for further investigation, as they (and SNPs in LD with them) have not been previously identified as associated with glycaemic traits.

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