Barely Significant
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Macular Pigment Optical Density and Measures of Macular Function: Test-Retest Variability, Cross-Sectional Correlations, and Findings from the Zeaxanthin Pilot Study of Response to Supplementation (ZEASTRESS-Pilot).

Foods · 2016 · PMC5302333 · PMID 28231126

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highly significantno p-value reported
While the observed changes are, on average, not large, their direction was consistent and highly significant, providing proof of principle that ZX can also improve macular performance even in healthy subjects.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.