The control of translational accuracy is a determinant of healthy ageing in yeast.

Open Biol · 2017 · PMC5303280 · PMID 28100667

Europe PMC DOI

hedged sentences

0.2000

closest p · 4.0× alpha

0.9600

boldest claim

The sentences

of borderline significancep = 0.20not close (p > 0.1)

Very low growth rates appear to reduce amino acid misincorporation, although the effect was overall of borderline significance with p = 0.20 for His misincorporation on CGC codons and p = 0.02 for Lys misincorporation on AGG.

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highly significantp = 0.96not close (p > 0.1)

Moreover, we observed similar interactions with Hsp70 family members and these were surprisingly isoform-specific, with deletion of the SSA4 gene, but not of the SSA1 gene, producing a highly significant interaction with paromomycin treatment ( p = 0.96 for ssa1, p = 0.005 for ssa4 ).

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