Applying phasor approach analysis of multiphoton FLIM measurements to probe the metabolic activity of three-dimensional in vitro cell culture models.

This observation is highly significant in that FLIM can be used as a non-invasive characterisation method to elucidate the metabolic kinetics in 3D in vitro models; therefore, suggesting a future usability of FLIM to various applications including the screening of pharmaceutical reagents and novel drug candidates on 3D cell-based in vitro assays.

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