Impact of saturable distribution in compartmental PK models: dynamics and practical use.

J Pharmacokinet Pharmacodyn · 2017 · PMC5306145 · PMID 28050672

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highly significantno p-value reported

Starting from a conventional three compartment PK model, transformation of one of the two peripheral compartments to a low capacity, high affinity compartment with saturable distribution resulted in a highly significant improvement of the model fit.

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