The breast cancer susceptibility-related polymorphisms at the TOX3/LOC643714 locus associated with lung cancer risk in a Han Chinese population.

The linear-by-linear association test revealed that except rs3104746 ( P = 0.638), the risk allele G of both rs9933638 and rs12443621 showed an increasing trend from light smoking to heavy smoking groups ( P = 0.004 and P < 0.001, respectively, p trend < 0.001, Table 4 ).

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Moreover, though a marginally significant difference of rs3095661 alleles was found between controls and cases ( P = 0.041, Table 2 ), no significant difference of rs3095661 genotypes was found in the four models between controls and cases ( P = 0.362, P = 0.066, P = 0.999, P = 0.197, respectively, Table 3 ).

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