The microtubule plus-end-tracking protein TACC3 promotes persistent axon outgrowth and mediates responses to axon guidance signals during development.

Although the relative reduction in MT growth speed when TACC3 is overexpressed is only slightly less compared to controls and is not quite statistically significant (0.91 ± 0.06 n = 21 versus control 0.82 ± 0.04 n = 22, ns p = 0.2, Fig. 2a ’), for other MT growth parameters, TACC3 OE significantly dampens the nocodazole-induced reduction in lifetime (0.99 ± 0.047 n = 21 versus control 0.86 ± 0.03 n = 22, * p = 0.03, Fig. 2b ’) and length (0.91 ± 0.08 n = 21 versus control 0.68 ± 0.04 n = 22, * p = 0.01, Fig. 2c ’) compared to controls.

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