The non-coding variant rs1800734 enhances DCLK3 expression through long-range interaction and promotes colorectal cancer progression.

Intriguingly, we identified a correlation between rs1800734 and DCLK3 expression in the healthy ( P =0.029, linear regression model) and tumour ( P =0.031, linear regression model) samples, and this association was highly significant in the MSS patients ( P =0.004, linear regression model) ( Fig. 2e ), indicating this locus may act as a distal enhancer and regulate DCLK3 .

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