The emergence of the PAX8 pathway from our agnostic genome-wide approach evaluating overrepresentation of SOC risk SNPs in 615 gene sets each containing putative targets of a different TF followed by replication in independent samples and methodological replication is highly significant given recent calls for an improved understanding of the role of PAX8 in SOC biology ( Bowtell et al , 2015 ) .
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Enrichment of putative PAX8 target genes at serous epithelial ovarian cancer susceptibility loci.
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