Mesoderm-specific Stat3 deletion affects expression of Sox9 yielding Sox9-dependent phenotypes.

However, at P4 ( Fig 4B and 4E ) and dramatically at P7 ( Fig 4C and 4F and S5A and S5B Fig ), there was a distinct and highly significant bowing of TCre;Stat3 flox/Δ mutant tibiae prior to the onset of incident fractures that were more prevalent by P7.

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