Intracellular growth of <i>Mycobacterium tuberculosis</i> after macrophage cell death leads to serial killing of host cells.

The higher stringency resulted in some values on the borderline of significance from previous version of the paper falling below the significance threshold this time.

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The probability of death increased significantly relative to bystanders and cells with less than 10 Mtb when more than 30 Mtb were internalized per cell over the course of the movie, and a threshold for Mtb to induce death was clearly visible in Figure 1 at about 50 Mtb internalized, with differences relative to bystander and lightly infected cells becoming highly significant ( Figure 1—figure supplement 5B ).

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