An exploratory assessment (see Additional files 4 and 5 ) of the relationship between 6MWD, PVR, and steady-state concentrations revealed a significant relationship for 6MWD, whereas only a small trend could be seen for PVR across the concentration range observed (Additional files 6 and 7 ).
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Efficacy of 1, 5, and 20 mg oral sildenafil in the treatment of adults with pulmonary arterial hypertension: a randomized, double-blind study with open-label extension.
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