Osteosarcoma cell proliferation and survival requires mGluR5 receptor activity and is blocked by Riluzole.

PLoS One · 2017 · PMC5322947 · PMID 28231291

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highly significantno p-value reported

Treatment with DHPG (50 μM), a group I metabotropic receptor (mGluR1 and mGluR5) agonist, increased the total number cells as assessed by DAPI staining, and the increase in Ki-67 positive cells over that of control sample was highly significant (p value of 0.01) ( Fig 5B ).

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