More recently, a multitude of gene association and genome-wide association studies (GWAS) have identified MAPT as a highly significant genetic risk factor for sporadic Parkinson’s disease (PD), despite the lack of obvious tau tangles in the majority of PD patients 14 15 16 17 18 .
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Increased 4R tau expression and behavioural changes in a novel MAPT-N296H genomic mouse model of tauopathy.
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