As could be expected, aphidicolin treatment resulted in a highly significant 2.1-fold decrease in the abundance of BrdU-positive cells in the regenerating RNC (16.05 ± 1.14% vs 34.06 ± 1.66%, mean ± standard error, in aphidicolin-treated and control DMSO-treated animals, respectively) (Fig. 1 a , e , f , Additional file 4 ).
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Inhibition of cell proliferation does not slow down echinoderm neural regeneration.
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