Mathematical modeling links Wnt signaling to emergent patterns of metabolism in colon cancer.

These observations suggest that there are likely to be significant changes in Wnt signaling dynamics and metabolic programming of treated tumors, perhaps as a means of coping and surviving the loss of nutrient and cellular damage.

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We checked for changes in expression of Wnt ligands, and although there was a trend toward significantly increased expression of Wnt2, Wnt5b, Wnt8b, and Wnt10b specifically in the tumor and not the neighboring normal tissue, the changes did not quite reach statistical significance (Fig EV2 A and B).

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