Latrophilin receptors: novel bronchodilator targets in asthma.

Proliferation was blocked in asthmatic IASMC by either the phosphoinositide 3 kinase inhibitor, LY294002 (3 μM), or a trend towards significance with the mitogen-activated protein kinase kinase (MEKK) inhibitor, PD98059 (10 μM) (p=0.002 and p=0.076, respectively, Friedman test, Dunn's correction) ( figure 3 B), which blunted extracellular regulated kinase (ERK) phosphorylation ( figure 3 C, D).

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