Mutations in tropomyosin 4 underlie a rare form of human macrothrombocytopenia.

Logistic regression analysis showed that the correlation between the proportion of proplatelet-forming cells and RNA and protein levels for TPM4 was highly significant ( P < 2 –16 and < 6.23 –12 , respectively) ( Figure 8A ), demonstrating that the level of TPM4 is rate-limiting for platelet formation.

also in 132,142 other papers