Genome-wide identification of splicing QTLs in the human brain and their enrichment among schizophrenia-associated loci.

When we performed a gene-set enrichment analysis of these 1,341 genes using the Database for Annotation, Visualization and Integrated Discovery 20 , we found highly significant enrichment of ‘SP_PIR_KEYWORDS: alternative splicing' (Benjamini-corrected P =8.6 × 10 −29 ) and ‘UP_SEQ_FEATURE: splice variants' (Benjamini-corrected P =1.1 × 10 28 ), which denote genes with known splicing isoforms ( Supplementary Data 2 ).

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