Individual Drusen Segmentation and Repeatability and Reproducibility of Their Automated Quantification in Optical Coherence Tomography Images.

31 However, drusen descriptors still rely in the characterization of RPE lifting properties across the entire macula region rather than the detection and identification of individual drusen (or clusters of them), not permitting the extraction of a number of features from individual drusen that may be significant in AMD progression, such as the number of drusen, individual drusen volume, and area, distribution, or reflectivity properties. 9 Apart from accuracy requirements, it is also important to assess the repeatability and reproducibility of the quantitative features that may be extracted to characterize drusen from the resulting outlines.

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