Increasing numbers of AOM episodes resulted in an overall trend toward higher anti-Ply IgG titers ( Fig. 3A ) and neutralizing titers ( Fig. 3B ), but overall, there was no difference in anti-Ply antibody potency ( Fig. 3C ) regardless of the number of AOM episodes.
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Otitis-Prone Children Produce Functional Antibodies to Pneumolysin and Pneumococcal Polysaccharides.
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