c-Abl inhibits breast cancer tumorigenesis through reactivation of p53-mediated p21 expression.

Conversely, mutant p53 expression trended to reverse the overall survival benefit provided to breast cancer patients whose tumors retain high expression of c-Abl ( Supplementary Figure S6 ), a finding that is highly significant in light of the fact that mutant p53 can promote oncogenic TGF-β signaling [ 57 ].

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