Barely Significant
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MDM4 actively restrains cytoplasmic mTORC1 by sensing nutrient availability.

Mol Cancer · 2017 · PMC5341177 · PMID 28270148

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highly significantno p-value reported
This is highly significant in the tumors lacking wild-type p53 (Fig. 6a , r 2 = 0.11) suggesting the possible development of MDM4 anti-tumor activities especially in the absence of functioning p53.

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