Clonal and microclonal mutational heterogeneity in high hyperdiploid acute lymphoblastic leukemia.

There was a highly significant co-occurrence of microclonal mutations in KRAS and NRAS codons 12 and 13, with 28 mutations found in only 19 patients compared with a predicted distribution of 23.8±2.1 ( p = 4.8×10 −4 ; Z-score = −3.3) ( Figure S8 ).

also in 132,142 other papers