Promoter methylation patterns of ABCB1, ABCC1 and ABCG2 in human cancer cell lines, multidrug-resistant cell models and tumor, tumor-adjacent and tumor-distant tissues from breast cancer patients.

Oncotarget · 2016 · PMC5341984 · PMID 27689338

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highly significantp < 0.001actually significant

In addition to the DNA methylation changes observed for ABCB1 and ABCG2 , selection of GLC-4 cells for resistance to adriamycin was associated with a highly significant decrease (from 89 to 65%, p < 0.001) in the DNA methylation status of LINE-1 (long interspersed nuclear element 1), a surrogate marker of global DNA methylation (data not shown).

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