γIR/PI-103-induced cell death was slightly reduced (for GBM4, the reduction almost reached statistical significance: p = 0.05), correlating with reduced levels of cleaved caspase 3 (Figures 6C, 6G , and S6 ).
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FoxO proteins or loss of functional p53 maintain stemness of glioblastoma stem cells and survival after ionizing radiation plus PI3K/mTOR inhibition.
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