Epigenome-wide association study of smoking and DNA methylation in non-small cell lung neoplasms.

The analyses also identified several highly significant methylation loci at the TSS and near exon 1 of PLA2G6 (Figure 2C ).

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The binary-smoking external validation analyses also identified cg24823993 as a marginally significant methylation site. cg22515201 in a CpG island within 200 bp of the TSS in PLA2G6 is the most significant CpG locus in the gene associated with cigarette smoking.

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