A novel mechanism of action of HER2 targeted immunotherapy is explained by inhibition of NRF2 function in ovarian cancer cells.

Oncotarget · 2016 · PMC5342785 · PMID 27713148

Europe PMC DOI

hedged sentence

—

closest p

—

boldest claim

The sentences

highly significantno p-value reported

Whilst Trastuzumab and Pertuzumab caused significant induction of NRF2 expression, their combination strikingly resulted in the profound and highly significant down regulation of NRF2 expression.

also in 132,142 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.