Altered RECQL5 expression in urothelial bladder carcinoma increases cellular proliferation and makes RECQL5 helicase activity a novel target for chemotherapy.

There was a highly significant increase in nuclear staining of RECQL5 in the malignant samples (Figure 1B , Contingency Table Pearson Chi-square test P=3.7×10e-17), with 90% of the malignant bladder samples scoring positive for RECQL5β compared to normal bladder samples where 83% of samples were negative for any nuclear staining.

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