Prion-specific and surrogate CSF biomarkers in Creutzfeldt-Jakob disease: diagnostic accuracy in relation to molecular subtypes and analysis of neuropathological correlates of p-tau and Aβ42 levels.

In a selected group of 50 cases with typical spongiform change and mild to moderate neuronal loss, we found a highly significant positive correlation between the amount of this prion-specific tau deposition and p-tau levels in the CSF ( r = 0.564, p < 0.001; n = 50) (Fig. 6 a).

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