We further examined the effect of BIBF1120 on gene expression of major fibrosis-related parameters Collagen I, TGFβ1, TIMP1 and ITGA5 and observed highly significant down-regulation in the expression levels of these parameters as shown in Fig. 2B .
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Tyrosine kinase inhibitor BIBF1120 ameliorates inflammation, angiogenesis and fibrosis in CCl<sub>4</sub>-induced liver fibrogenesis mouse model.
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