Paired assessment of liver telomere lengths in hepatocellular cancer is a reliable predictor of disease persistence.

In paired samples, telomere shortening was observed in both sets of patients with HCC, who had either pre-existing serologically confirmed either hepatitis B or hepatitis C infection, but not in HCC patients without pre-existing HBV or HCV infection (mean ± S.E.M., 0.82 ± 0.02 (control), 0.81 ± 0.01 (HCC without HBV or HCV infection), 0.47 ± 0.01 (HCC + HBV), and 0.43 ± 0.01 (HCC_HCV), SS3.15, MS 1.58, F 195.29, P <0.001, ANOVA; between groups comparison, M1 or M4 compared with M2 and M1 or M4 compared with M3, but not M1 compared with M4, were highly significant, P <0.01, Tukey’s HSD test) ( Figure 1 A).

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