Age-dependent dopamine transporter dysfunction and Serine129 phospho-α-synuclein overload in G2019S LRRK2 mice.

Indeed, significant reductions of HVA/DA and 3-MT/DA ratios in G2019S KI mice were found, the reduction of DOPAC/DA ratio being close to significance ( p = 0.067; Table 1 ), suggesting a slower DA metabolism in G2019S KI mice Microdialysis also revealed that the LRRK2 kinase inhibitor Nov-LRRK2-11 (10 mg/kg, i.p.), which normalizes motor performance in G2019S KI mice [ 43 ], did not affect striatal DA release in any genotypes (Fig. 4a ), suggesting the motor phenotype of G2019S KI mice did not rely on greater DA release.

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