CLImAT-HET: detecting subclonal copy number alterations and loss of heterozygosity in heterogeneous tumor samples from whole-genome sequencing data.

Moreover, we compute the Pearson correlation coefficient (r) and mean absolute error (MAE) for cellularity estimations, and the results show that the estimated cellularity of CLImAT-HET has a highly significant positive correlation (r > 0.99, p -value < 5 × 10 −5 , MAE < = 0.02) with the underlying cellularity across all simulated samples (Fig. 3a , b and c ), which demonstrates CLImAT-HET’s ability to precisely recover clonal architecture.

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