Depletion of BLM and EXO1 simultaneously resulted in a significant reduction of cytosolic DNA foci in the nonirradiated MDA-MB-231 samples and a highly significant reduction in the irradiated MDA-MB-231 and HCC1806 cell lines compared with the control siRNA-treated ones ( Fig. 2 C–E).
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A prosurvival DNA damage-induced cytoplasmic interferon response is mediated by end resection factors and is limited by Trex1.
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