However, it has shown that (1) there is low-quality, but statistically highly significant, evidence that 200 mg/day effectively reduces inflamed lesion counts; (2) side effects, in particular menstrual irregularities, are dose-related; and (3) concomitant use of a COC significantly reduces the incidence of menstrual disturbances.
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Oral Spironolactone for Acne Vulgaris in Adult Females: A Hybrid Systematic Review.
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