Janus-faced Acrolein prevents allergy but accelerates tumor growth by promoting immunoregulatory Foxp3+ cells: Mouse model for passive respiratory exposure.

Mice sensitized to KLH (group K) formed antigen-specific IgG1, IgG2a, IgE and IgA antibodies, but co-exposure of mice to acrolein (group KA) led to a highly significant reduction in the production of all these immunoglobulins classes to the otherwise very immunogenic protein KLH ( Fig. 1 ).

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