Clinical outcomes based on multigene profiling in metastatic breast cancer patients.

In univariable analysis of RFS, age, clinical subtype, tumor grade, stage at diagnosis, administration of neoadjuvant or adjuvant chemotherapy and type of surgery were all significant or marginally significant predictors of outcome (Table 2 ).

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There was discordance in potentially actionable genes such as PIK3CA with both gains and losses seen, with a slight trend towards enrichment for TP53 mutations and mutations in the MAPK pathway in metastases/recurrences.

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